Cincinnati Children's Hospital Medical Center

Recognized as a Center of Excellence on 4/17/2018. Public Announcement

Airbnb options to supplement CCHMC lodging suggestions

Phone: 513-636-4726

Address: 3333 Burnet Ave, Cincinnati, OH 45229 as well as numerous satellite locations in the greater Cincinnati area

Number of Outpatient CCM appointments in 2017: 69

Number of Inpatient CCM Patient Days in 2017: 83

Number of CCM Research Publications, 2012-2017: 8

Core Faculty

Medical Director: Sudhakar Vadivelu, DO,  Department of Neurosurgery

Nurse Coordinator: Lisa Neiser, RN

Neurologist: John Michael Taylor, MD, Department of Neurology

Epileptologist: Francesco Mangano, DO, Department of Neurosurgery

Genetic Counselor: Katie Wusik, LGC, Department of Human Genetics

Additional Faculty

     Neurosurgery: Mario Zuccarello, MD

     Neurology: Steve Wu, MD

     Neuropsychologist: Anna Byars, PhD

     Neuroradiologist: James Leach, MD

     Stroke Rehabilitation: Douglas Kinnett, MDAndrea Paulson, MD

     Neurodiagnostic Testing: Douglas Kinnett, MD

      Researchers: Elisa Boscolo, PhDAdrienne Hammill, MD, PhDLori Luchtman-Jones, MD

Summary of Cincinnati Children's Research Program

The Cerebrovascular Center at Cincinnati Children’s Hospital Medical Center has active benchside and clinical research interests as it relates to cerebral cavernomas:

  • In collaboration with our translational vascular biology research program, individual laboratory research interests include exploration of developmental aspects of low flow vascular malformation and in elucidating the role for stem cell and progenitor differentiation to mature vascular cells in hopes for identifying molecular and genetic targets for future pharmacotherapeutics. 
  • Candidate drugs are evaluated in the murine malformation models (venous malformation, hemangioma, and lymphatic malformations) for potential efficacy in preventing lesional growth and pre-clinical supportive evidence.
  • Benchside research interests include understanding how various genes contribute to cerebrovascular development both in the global framework in early normal vascular development as well in terms of organ and tissue-specific regulation, in particular, Notch signaling aberrations in the cerebrovasculature.   
  • We have an ongoing clinical study evaluating mental health in children diagnosed with cerebral cavernomas. Our long-term goal here is to elucidate clinical management factors that affect mental health in children in comparison to other chronic medical conditions. Our immediate objective here is to understand the importance of needing to evaluate mental health metrics and further identify best clinical tools for measurement. 
  • We examine classification schema for developmental venous anomalies and the neuroimaging based architectural clues they may give us to their behavior. 

Patient Education includes a dedicated webpage for cavernous malformation, use of Angioma Alliance Patient Booklets, annual patient conferences, and telehealth services.

Medical Education includes grand rounds, journal club, invited expert speakers, and dissemination of the Angioma Alliance Clinical Care Consensus Guidelines.


Last updated 6.27.2018